At 6 months, 92% of patients respond positively to Cingal, with a pain reduction of 72% ¹

Cingal has the strongest clinical trial data of any other injectable for OA pain management. Within the first week of treatment, patients experience a 59% reduction in pain, with 89% responding in that time frame.

How does Cingal Work?

Mechanical effect 

The HA within Cingal binds well to water, producing a viscous, jelly-like consistency that provides lubrication and acts as a shock absorber within the joint, quickly improving the mechanical characteristics of the joint by improving lubrication and cushioning.

Protective Effect

HA has a biomechanical structure that protects cartilage when surrounding chondrocytes. Cingal is scientifically proven to still protect the joint even with a steroidal component.

Analgesic effect 

After the steroid has helped to manage pain quickly, (within 48 hours) the HA diminishes nerve impulses and the sensitivity of nociceptive nerve endings so helps to further dampen pain responses for a much longer period of time compared to steroids alone.

Safe – Best of both worlds.

You may have heard of concerns about using steroid treatments for joint pain.  There is some clinical data that describes repeated steroidal injections can harm and damage the joint.  This is because the typical type of steroid used as a lone injection is toxic to the cells that make cartilage.  Cingal is formulated with a steroid type that is slower release and has lower toxicity to joint cartilage cells than other steroid types. However the real safety element to Cingal is in the formulation with hyaluronic acid.  Scientific testing has proven that while the steroid in Cingal does the job to control pain and inflammation, it is not toxic to these cells and the HA maintains it naturally protective nature²

Indications 

Cingal is indicated as a viscoelastic supplement or a replacement for synovial fluid in human knee joints. Cingal is well suited for rapid and long-term relief of the symptoms of human knee joint dysfunctions such as osteoarthritis. The actions of Cingal are long-term relief of symptoms by lubrication and mechanical support supplemented by short-term pain relief provided by triamcinolone hexacetonide. 

References

1: Hangody L, et al. Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial. 2: Bauer, C.; Moser, L.B.; Jeyakumar, V.; Niculescu-Morzsa, E.; Kern, D.; Nehrer, S. Increased Chondroprotective Effect of Combining Hyaluronic Acid with a Glucocorticoid Compared to Separate Administration on Cytokine-Treated Osteoarthritic Chondrocytes in a 2D Culture.